Skip to Main Content

Conducting a Literature Review

The Clinical Question

MOST COMMON TYPE OF CLINICAL QUESTIONS:

THERAPY determining the effect of interventions on patient-important outcomes
DIAGNOSIS establishing the power of a test to differentiate between those with and without a target condition or disease
HARM ascertaining the effects of potentially harmful agents on patient-important outcomes
PROGNOSIS estimating a patient's future course

4 ELEMENTS OF THE CLINICAL QUESTION (PICO) - use for therapy questions

 QUESTION/STUDY DESIGN
 PICO Worksheet  PICO Tutorial

 

Patient

What are their most important characteristics?

  • primary problem
  • disease state
  • co-existing condition

Describe your patient specifically:

  • Sex
  • Age
  • Ethnicity
  • Socioeconomic factors

ALWAYS include this piece in your search.

Intervention

What do you want to do for the patient?

  • Order a test
  • Prescribe a drug
  • Order a procedure

Other considerations:

  • Main intervention
  • Prognostic factors
  • Exposures

Almost always include this piece in your search.

Comparison

What is the alternate intervention, if any?

  • A different drug
  • No medication
  • A Placebo
  • A different test
  • A different procedure

It is less common to include this piece in a search

Outcome

What are you hoping to achieve, measure, or change for the patient?

  • Alleviate symptoms
  • Improve test results
  • Reduce adverse events
  • Improve function

Could also be the result NOT desired.

Sometimes include this piece in your search.